Gene Therapy Trial in Newborn Monkeys Shows Long-Term HIV Protection
Researchers have developed a gene-therapy approach that provides long-term protection against HIV in newborn monkeys. By delivering a gene that produces an antibody to block the CCR5 receptor—the entry point HIV uses to infect cells—a single shot was able to shield the animals from the virus for at least three years. These findings were among the highlights of the Conference on Retroviruses and Opportunistic Infections (CROI 2026) in Denver. While the results offer a promising signal toward a functional cure and the ability to control the virus without antiretroviral therapy, experts noted that the search for a cure continues to be marked by both breakthroughs and sobering setbacks.
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The search for a way to control HIV without antiretroviral therapy (ART) continued to generate both promising signals and sobering setbacks at the recent Conference on Retroviruses and Opportunistic Infections (CROI 2026) in Denver. Here are five highlights.
Diagnosed in 1992, Loreen Willenberg devoted much of her life to ensuring that people with HIV would one day benefit from her unique biological gift. ... Researchers delivered a gene into the animals that produces an antibody blocking CCR5, a receptor on cell surfaces that HIV binds to establish ...
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